1.3.2 Live cell imaging, software tools
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Module description: Examining protein distributions and dynamics in live cells using high-resolution bio-imaging methods and biophysical techniques can reveal information about the real-time activities of cell signaling networks. Modeling the temporal changes that can be observed with fluorescence microscopy and their relationship to protein function along complex signaling pathways can help to shed light on the underlying mechanisms that regulate cell signaling.
Fluorescence imaging microscopy not only complements the existing biochemical, genetic and physiological techniques for studying cellular function, but also adds information on subcellular localization and temporal resolution. The development of genetically encoded VFP-tags and the use of QDs have significantly advanced the use of fluorescence microscopy in cell biology. These advances have enabled the quantification of dynamic processes along signaling pathways in the context of the living cell.
Some examples of software for live cell imagine are:
- Invivo analyzer developed by MediaCybernetics: the InVivo Analyzer Suite combines InVivo with Image-Pro Analyzer and Image
- Pro's 3D Constructor tool for seamless sharing of images and information as well as intuitive acquisition, advanced analysis tools, and sophisticated 3D rendering and measurement features.
- Andor iQ Software
- UltraVIEW(R) VoX system developed by Perkin Elmer: is a complete 3D live cell imaging solution, incorporating the latest developments in spinning disk technology, which allows scientists to acquire images, along with market-leading software to visualize, measure, track, chart and publish exceptional 4D multi-channel images.
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